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Although the distinction between candidate and established variants is not crystal clear and findings from genome-wide association studies may be robust, we can expect that the predictive value of variants that are less convincingly established is less likely to be replicated in independent populations.
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There is a lack of interventional studies and what is less established is the relative benefit of smoking cessation interventions (SCIs) in the stroke population.
In comparison with existing results, the established criterion is less conservatism thanks to the double integral term of the LKF.
While the role of dysferlin in membrane repair is well established, it is less clear how the protein is regulated.
However, the role for IL-23 in established disease is less clear.
Thus, although established COPD is less common in young adults, the disease process is likely to begin at a younger age.
Less well established are the benefits of green roofs to property owners and developers.
In general hospitals where resuscitation teams have been established, the percentage is less satisfactory.
With clearly established criteria, there is less concern about subjective evaluation.
Whereas, with an established business, there is less risk and a higher ceiling for sustained success.
Of course, well established propositions are less likely to be challenged than those that are novel, and they are more handily defended.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com