Sentence examples for established irreversible from inspiring English sources

Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype.

They may be identified by detection of abnormal serum and/or urine levels of bone, synovium and/or cartilage degradation/turnover markers, prior to established, irreversible damage being identified using one or more imaging modalities.

The aim of the clinical tests is not to probe every neuron within the intracranial cavity to see if it is dead an impossible task but to establish irreversible loss of brain-stem function.

However, only few studies showed or discussed the possibility of establishing irreversible phenotypes through cycling hypoxic exposure without genetic manipulation [ 41, 42].

Stunting and its consequences, once established, are irreversible beyond the age of two.

In 1979, when the Islamists overtook the popular revolution and established an irreversible Islamic Republic, they made all range of promises - women's rights, freedom of religion, freedom of the press, open government, freedom, freedom, freedom.

CAN, once established, is irreversible [ 3, 23].

In the USA, The Uniform Determination of Death Act specifies that death may be declared after appropriate diagnostic tests establish either "irreversible cessation of circulatory and respiratory functions" or "irreversible cessation of all functions of the entire brain, including the brain stem" [ 7].

Similarly, p38MAPK/MAPKAPK-2 pathway is activated in H2O2-treated human stem cells and is responsible for establishing an irreversible cell cycle arrest typical of senescence that is caused by permanent reactive oxygen species (ROS) production, where increased functional mitochondria are involved (Borodkina et al., 2014).

A final determination of tritiated water permeability was compared with initial values to establish any irreversible alterations in epidermal barrier function induced by contact with the glycol ethers.

Furthermore, hydrophobic interactions appear to be the dominating attraction force in cellulase binding to lignin, while a number of other interactions may establish the irreversible binding.