Sentence examples for established inducer of from inspiring English sources

TGF-β is well established inducer of EMT.

Interestingly, we also observed significantly reduced DNA binding of NF-κB subunits in HIF-1α-deficient cells after stimulation with TNFα, a well established inducer of NF-κB activity [44].

STS is an established inducer of caspase-mediated apoptotic cell death in neurons.

Here, we investigated whether c-Src kinase, an established inducer of invasive states, contributes to the progression from ALH/LCIS to ILC.

To determine the role of PARP-1 on the survival of myotubes, we incubated myotubes with H2O2 (300 μM for4 h), because H2O2 is the most stable form of ROS and an established inducer of PARP-1 activity [ 42].

Indeed, tumour growth factor β (TGFβ), which is an established inducer of EMT [ 70], promotes the phosphorylation of eIF4E via activation of ERK (extracellular signal regulated kinase) and p38 MAPK, which phosphorylate Mnk [ 71].

In animal models of sepsis, there is a down regulation of the PI3K/Akt pathway that may be the consequence of TLR4 activation and downstream in activation of well established inducers of insulin resistance as JNK, IKK-β and iNOS.

In order to investigate the ability of HO-1 to protect against A β toxicity, cells were exposed to two established inducers of this enzyme.

The more profound effect of EL overexpression as compared to single LPC on MIP-2 plasma levels might be explained by a sustained EL-mediated provision of a mixture of LPC but also FFA, which are established inducers of IL-8.

(1) We have shown that the episialin promoter is positively regulated by STATs (signal transducers and activators of transcription) in T47D breast and other carcinoma cell lines, using several established inducers of episialin expression (eg IFN-? and IL-6) as STAT-activating ligands [ 3].

To this end, cells were treated with additional chemotherapeutics and established inducers of intrinsic apoptosis, such as PKC inhibitor staurosporine or transcription inhibitor actinomycin D. These compounds failed to induce CHOP (Supplementary Figure S1C), so effects are independent from this protein.