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When these animals were subjected to EAE induction, they were found to be resistant to disease despite the fact that appropriate T cell responses were normally established in the periphery.
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It is well established that in the periphery, stimulation of thyroid gland activity by the cold, or direct administration of T3, promotes thermogenesis and catabolic activity (Tomasi and Horwitz, 1987).
The same period also saw more anti-Abbasid regimes established on the periphery of the Islamic world: the Fatimids seized power in Ifriqiya, and another Zaydi dynasty was established in Yemen.
New, woven bone was established at the periphery while fibrous tissue was still present in the centre; no cartilage or other signs of enchondral ossification were detected.
An alternative scenario is that a small P. infestans metapopulation was established at the periphery of its center of origin, or even outside Mexico, possibly in North America, some time before the first global P. infestans pandemic.
Bandar TunRazak is one of the established towns within the periphery of Kuala Lumpur.
During embryonic shoot meristem formation, the two basic functions of the meristem need to be established in spatially separated domains: stem cell maintenance in the meristem center, and organ initiation in the periphery [ 3, 40].
Intriguingly, despite aged and young NK cells being provided in the BM inoculum at a 1 1 ratio (Fig. S3B), NK cell chimerism in the BM and periphery was not proportionally established in both environments at weeks 2 and 6 postchimerism as assessed by the absolute number (Fig 3D and E).
We previously established in healthy donors that most autoreactive developing B cells were removed either in the bone marrow or in the periphery, revealing two B-cell tolerance checkpoints.
To conclude, this report establishes the expression signature within Tregs in the periphery, during the period right after the clinical onset of T1D.
This kind of difference is not visible in the periphery, as already established AD and VaD cases had similar levels of TNF- α and IL-1 β levels, when compared to each other and to healthy controls [ 45].
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