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In the past similar techniques have been applied to large scale studies but it sperformance is yet to be established in small scale clinical studies thus the contribution of this paper is in justifying the validity of these techniques for small samples too.
There is no gold standard for animal testing but proof of principle can be established in small rodents.
These models are, however, mainly established in small animals (rats or mice) and mostly unavailable for the assessment of safety and efficacy of extracorporeal support systems [19].
Carménère has also been established in small amounts in New Zealand.
The first level of medical organisations are mainly established in small cities and towns or in the countryside, e.g. town hospitals, health centres in the city, regional hospitals and the hospitals are run by mines and/or other enterprises.
Although the antitussive effects of codeine in patients with chronic bronchitis were established in small patient populations, and there have been no double-blind, placebo-controlled studies of codeine in cough due to acute bronchitis, it is reasonable to presume that codeine is effective under these circumstances [ 39].
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In recent weeks four more corralas have been established in smaller towns in Andalusia and another in the city of Málaga, where the unemployment statistics and the number of empty houses are even higher than in Seville.
Other preventive measures such as prophylactic cranial radiotherapy, while well established in small-cell-lung cancer, is not routinely used in breast cancer, as no survival benefit was observed so far (Saip et al, 2009).
On the other hand, larger animals, such as dog and sheep, are very expensive and not appropriate to establish new experimental conditions, although they are useful for testing approaches established in smaller animal models.
Another factor possibly related to the pattern observed is population density: in small frogs, a viable population could be established in smaller ranges than in large frogs [ 51], potentially driving the correlated evolution of microendemism.
Venligboerne (Friendly citizens) was established in the small Danish town of Hjørring in North Denmark in November 2014 by Merete Bonde Pilgaard.
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