While these compounds establish in principle that Hsp90 is a "druggable" target from a pharmacology perspective, poor solubility and non-specific toxicities make them unsuitable for use in humans.
While our new simulations establish in principle that E-I based attractor networks can generate grid outputs even when spatial firing of many E and I cells in the network is not clearly grid-like, the extent to which these networks can account for all details of experimental observations, including the weak periodic pattern referred to by the reviewer, is not yet clear.
All experiments with mice were performed in accordance with the guidelines established in the Principles of Laboratory Animal Care (directive 86/609/EEC) and approved by the Italian Ministry of Health.
All animal procedures were performed in accordance with the Institutional Animal Care and Use Committee (IACUC), in compliance with the guidelines established in the Principles of Laboratory Animal Care (directive 86/609/EEC) and approved by the Italian Ministry of Health.
As a trade-off between water and energy consumption is established in this design principle, the water and energy consumption could be optimized at one step.
Stereology avoids the need to correct for variation in section thickness and cell size of each case as established in the Abercrombie principle [ 28, 32], with confident, unbiased live counting of neurons at high magnification using 63 or 100× objectives.
Mathematics is established in old trusted principles and processes while constantly adapting and changing with new ideas and discoveries.
Such actions are rare, but the House of Lords precedent established that, in principle, employees have the right to seek compensation.
The first written law of succession, dating from this coronation, established primogeniture in principle and the prior right of legitimate royal sons to the crown.
While civil rights legislation established equality in principle many practical barriers remain to achieving economic and social parity.
