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How do chromosomal rearrangements become established in organisms in which they cause infertility when heterozygous?
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Prediction of PPIs is made possible in organisms lacking experimental determination of PPIs using the PPI networks established in reference organisms.
The opposite pattern, high AT content being correlated to a highly basic proteome, is well established in intracellular organisms (e.g., [76]).
The concept that a regulatory niche creates an essential and supportive microenvironment for stem cells has been well established in several organisms and lineages [45].
One of the most common scaffolds established in multiple organisms is Miller's [ 28 ].
Although the role of this enzyme is well established in lower organisms, the information on its role in higher plants is scarce.
The role of short ncRNAs as powerful regulators of gene expression is well accepted and established in complex organisms reviewed in Moazed (2009).
Links between CpG DNA methylation and histone methylation have been established in other organisms, including plants (Tariq and Paszkowski 2004) and mammals (Rose and Klose 2014).
It is well established in prokaryotic organisms that DNA repeats can mediate genomic rearrangements that can alter the expression of disease-associated genes [ 26].
Several observations point to the need to systematically investigate the pathogenic roles of shared, or pleiotropic genes: their importance is well established in model organisms and monogenic diseases [ 1- 3].
Although Tln2 is reported to be the ancestral gene [4], the specific function of talin2 protein has not been established in any organism.
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