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Stratigraphic influence on structural style and strain distribution in deformed sedimentary sequences is well established, in models of 2D mechanical stratigraphy.
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To this end we use a combination of a novel approach for quantitative, rigorous multiple-knockouts analysis based on the Shapley value from game theory, with an established in-silico model of Saccharomyces cerevisiae metabolism.
The cardioprotective effects of resveratrol are well established in animal models of metabolic disease but are yet to be investigated in a combined model of hypertension and diabetes.
Proof of principle has been established in animal models of Sjögren syndrome and lupus, pointing to the need for translational research to develop clinical trials.
While the cardioprotective role of MIF is thus well established in experimental models of myocardial I/R, data in human subjects are sparse.
Two neurodiagnostic studies of NMJ dysfunction have been established in mouse models of a human NMJ disorder called myasthenia gravis (Wu et al., 2001).
A participatory role of the intestine in gallstone formation has also been established in animal models of gallbladder disease.
Certainly, the neuroinflammatory paradigm of inflammatory actions on peripheral nerve sensitization is well established in acute models of inflammatory pain and chronic bowel diseases.
Finally, a role for dopamine and D2R has been established in animal models of obesity [2].
To further validate our high-confidence candidates, we established in vivo models of HD to investigate whether or not these genes are likely to be involved in mutant Htt toxicity and/or modification of mutant Htt aggregation in vivo.
The association between death-driven proliferation and cancer is best established in mouse models of hepatocellular carcinoma (HCC).
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