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Nonetheless, a definite role of p38 MAPK in CAR activation has yet to be established, given that activation of p38 MAPK appears to enhance some but not all target genes of hCAR.
Risk factors for ICC, on the other hand, are not so well established given that approximately 90% of ICC patients lack a recognized risk factor for the disease [ 12].
This might be further exaggerated once tumors are established, given that the leakiness in Apc mutant colonic adenomas in mice triggered further accumulation of IL-17 and IL-23 in the tumor stroma (Grivennikov et al., 2012).
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The secondary market for sovereign sukuks may be difficult to establish, given that there would be asymmetric information as to the quality of the underlying asset.
Causal link is difficult to establish given that sleep disturbance and aggressive behavior could be the symptoms of the same disorder.
A brief note is in order here on the relative chronology of Seneca's works, which is hard to establish given that we know so little about Seneca's life.
For AR-A, this is not difficult to establish given that this gene is present in a wide phylogenetic range of species.
The physiological relevance of this phenomenon is difficult to establish, given that sperm do not normally encounter high bicarbonate concentrations until in the oviduct.
A working hypothesis of CRPS (type I) was established given the reason that patient demonstrated disproportionate pain, hyperalgesia, edema, temperature asymmetry, skin changes, movement loss & absence of major nerve injury.
The results of measurements were in a good accordance with the variation laws theoretically established, giving the proof that measurements of pO2−, between about 2 and 12, are possible in the electrolytic and temperature range considered, by means of this system.
Given that TRN establishes topographical connections with its cortical inputs and thalamic outputs, we hypothesized that TRN could support local slow wave generation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com