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The DO-based estimate of BMCL10 is consistent with observed exposure toxicity in human subjects (Lan et al. 2004) and thus may provide a more appropriate starting point for establishing exposure thresholds that protect the most sensitive human subpopulations.
A cumulative Weibull predictive model was employed to estimate exposure thresholds.
Furthermore, uniform CO2 exposure thresholds, detailed dose-response models and specific CO2 pipeline regulation are absent.
Because no minimum exposure threshold has been established for food allergens (Bindslev-Jensen et al. 2002), and because it is believed that more stable proteins represent a greater allergenic risk, researchers have focused on the most persistent protein fragment when assessing allergenic risk (e.g., Astwood et al. 1996; Fu et al. 2002; Herman et al. 2004; Metcalfe et al. 1996).
Although no firm health and safety vibration exposure threshold limits have been established, the available data suggests that rail vehicle operators would probably fall under the proposed WBV "action levels" of the EU directive provisions for protection from physical hazards.
Larger studies are required to confirm this exposure threshold.
Our results may inform the exposure threshold issue.
The study also simulated how the fuel vapor was carried in the air to assess the potential for short- and medium-term benzene exposures, comparing their measurements to three established thresholds.
In an exposure response analysis, Järup and Åkesson (2009) noted evidence of adverse effects on kidney and bone at U-Cd concentrations of < 1 µg/g creatinine, raising a concern that the established thresholds might not provide sufficient protection.
Therefore, a score of ≤0.3 was established as threshold.
Microarray technology for the global analysis of gene expression may be a sensitive enough tool to address the low end of the dose-response curve down to and below ambient exposure levels, thereby providing a basis for establishing pragmatic thresholds.
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