Sentence examples for established disease model from inspiring English sources

This is an established disease model for type 2 diabetes.

The HLA-B27 transgenic rat model permitted the rapid treatment of an established disease model.

More recently, an IL-15-Fcg2a fusion protein was generated that prevented the development of CIA and also blocked disease progression in an established disease model.

Anti-TNF-α immunotherapy with TNF-K has a sustained but reversible therapeutic efficacy in an established disease model, supporting the potential suitability of this approach in treating human disease.

Because of the general relevance and global burden of cardiovascular disease [ 8], the present study was performed in a setting of experimental atherosclerosis using an established disease model, ApoE3Leiden mice which exhibit a unique human-like sensitivity to cardiovascular drugs [ 9].

Thus, for each pathogen the inoculum (cfu/ml) used for intracisternal infection was based on previously established disease models [ 9, 10].

Mutation data can provide accurate diagnoses, improve genetic counseling, help define disease mechanisms, establish disease models, and provide a basis for translational research and testing of novel therapeutics.

The effect of such immunotherapy on earlier, less established disease or cancer models is unknown.

Antagonism of GM-CSF can strikingly reduce established disease in mouse models of arthritis.

Moreover, antagonism of GM-CSF markedly reduces established disease in mouse models of RA and has a comparable effect to that of anti-TNF treatment [ 49].

Moreover, utilizing established disease measures in canine models provide sensitive and specific milestones of disease progression and therapeutic response that parallels surrogate markers used in human patients.