The role of P450s in the insect midgut has been well established in detoxification as well as possible pheromone synthesis [ 56].
Transcripts for Sec-containing proteins also fit into the theme of MoTTs because they correspond to important stress response proteins, with specific GPX and TRXR activities well established as cellular detoxification enzymes.
It is well established that the detoxification of H2O2 can be achieved through non-enzymatic (glutathione) and enzymatic ways; two different enzymatic systems, namely, catalase (CAT) and glutathione peroxidase (GPx).
The existence of a physical withdrawal syndrome after marijuana detoxification is established among scientists [ 8].
This rich data set will be useful for establishing pathways of detoxification as genes catalysing the three classic classes of drug metabolism (oxidation, conjugation and excretion) [ 23] would be expected to be co-regulated.
In 1987, the first heroin detoxification centers were established in in Lanzhou city, Gansu province in southwestern China, where illicit drug use is relatively common.
Due to the established role of GSTM1 in detoxification and the high frequency of homozygous deletions in the population, GSTM1 has been extensively investigated in association with many chronic diseases, in particular, with asthma [ 5] and different types of cancers [ 4, 6], including bladder cancer [ 7].
In addition, a model was established to describe the possible arsenic detoxification pathway in two strains.
Apart from this, the role of GSH-dependent detoxification reactions is well established in our study, as a large number of GSTs are upregulated under chromium stress.
The differential increment in the activities of GDH, GS and arginase and in the level of urea established three different alternative mechanisms of ammonia detoxification.
