Sentence examples for established correlate from inspiring English sources

Microneutralisation assays have regularly been used for these analyses, and titres of ≥40 have conventionally been taken to represent significant levels of antibodies (this significance is derived from it being four times the minimum level of antibodies that the assay can detect rather an established correlate of protection).

Both assays used to document the antibody response are functional assays, nevertheless, in absence of an established correlate of protection, it is unclear how the haemagglutination inhibiting and neutralising antibody responses documented in this study would translate to efficacy against infection or disease in a pandemic context.

The established correlate of protection also permits comparisons of new generation vaccines to older ones.

Given the lack of an established correlate of protection, the level of immune response that equates to protection is unknown.

Thrombocytopenia is already an established correlate to poor outcome in sepsis, and a platelet count, unlike the platelet membrane potential, is almost always readily available [ 4].

Furthermore, the established correlate of protection against meningococcal disease is the presence in the serum of bactericidal antibodies (i.e. antibodies that trigger the classical complement pathway and cause bacteriolysis).

There are no established correlates of protection against malaria either for natural immunity to the disease or for immunity conferred by candidate malaria vaccines.

This assay has limited sensitivity for avian strains [13] but has been used extensively by regulatory agencies and has established correlates of protection for seasonal human strains.

Not all established correlates could be confirmed longitudinally.

Aneuploidy and micronuclei are established correlates of increased cancer risk.

In this section, we investigate how ρ compares with other established correlates of evolutionary rate.