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These results led to a model in which sister chromatid cohesion is established concomitantly with DNA replication [ 8].
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We also established that concomitantly with impaired RT-induced apoptotic signalling, miRNA-214 overexpression increased p38MAPK and FoxO4 phosphorylation.
EBV transforms adult primary B cells into continually growing lymphoblastoid cell lines (LCLs) and concomitantly establishes type III latency in vitro.
Specifically, in the case of amperometric enzyme electrodes, electron-transfer pathways between the immobilised redox protein and the electrode surface have to be established allowing a fast electron transfer concomitantly avoiding free-diffusing redox species.
Additionally it is well established that diabetes and hypertension present concomitantly and often act synergistically to promote the pathological state via the induction of oxidative stress and inflammation [ 10, 21– 23].
Development initiatives in the 1930s-1970s attracted people to Bombas who provided additional labor, but concomitantly led to more opportunities being established outside the territory and to emigration of inhabitants, particularly younger ones, in search of a better life.
Vascular smooth muscle cell dysfunction likewise contributed to the progression of vessel disease in experimental models of diabetes and diabetic patients, albeit it remains presently unknown whether it occurred prior to, concomitantly or after impaired endothelial reactivity was established [ 1, 2, 4].
We previously showed that normal receptor endocytosis and internalized EGFR fate also depend on the ability of RIN1 to concomitantly activate ABL tyrosine kinases, consistent with the established role of ABL kinases in cytoskeleton remodeling and the growing evidence that such remodeling plays a role in endocytic processes.
In this study, we established that the NS1 A374G substitution induced a D125G coding mutation and concomitantly activated a novel donor splice site, hence producing the novel viral transcript and protein, NS3.
We believe that this case brings a word of caution to be considered when cancer immunotherapy is combined or concomitantly administered with hormone therapy, evidencing the delicate interactions established between the immune responses elicited by vaccines, the immune-modulating effect of sex hormones and tumor cells.
A particularly relevant application for our strategies is to screen for small molecule chemical chaperones that stabilise target proteins and concomitantly re-establish their biological functions [12].
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