In GeparTrio, centrally evaluated data on HER2 status (based on immunohistochemistry (IHC) and silver-enhanced in situ hybridisation according to ASCO/CAP guidelines (Wolff et al, 2007)) were used, as HER2 determination was not yet fully established at the time the study was conducted.
A protocol for thromboprophylaxis was established at the department before study start, two minor changes were performed during the study period (Table 1).
The significance of the k-RAS status was not established at the time of study accrual and hence no prerequisite for inclusion.
Unlike well-established alternative medicine centers featured at some hospitals [ 15- 17], our medical center had no complementary and alternative resources established at the time this study was conceived.
50 Also, a case control study design offers a practical, time-efficient and cost-effective method of assessment of diseases with long latency periods, such as in OSCC, as the diagnosis has already been established at the start of the study.
The study was established at the Iowa State University Field Extension Education Laboratory Research Farm near Ames, Iowa in November of 2004 through 2007.
The recent consensus states that the progression of keratoconus is best evaluated with additional thickness and posterior keratometric data [ 42]; however, this had not been established at the time of preparation of the study protocol.
Although not yet established at the time of data collection, the study approach was also consistent with the 2010 Tri-Council Policy Statement on research involving the First Nations, Inuit and Métis peoples of Canada [ 52].
The Shale Resources and Society Institute was established at the school in April to study shale gas and hydrological fracturing, also known as fracking.
Health care workers' access to the computerised malnutrition screening system was established at the beginning of the intervention study, in the clusters of the intervention arm.
