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Their liver function test, serum lipid profile, levels of lipid peroxidation and the activity of liver antioxidant enzyme glutathione were established at a dose level of 100 and 200 mg/kg.
The pharmacokinetic behaviour of vincristine in wild-type, Mdr1ab KO and Mdr1ab/Mrp1 TKO mice, 10 14 weeks of age, was established at a dose of 1 mg kg−1.
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DLT was established at a ZD2767P dose of 18.63 mg m−2 ×3 administrations and MTD at 15.5 mg m−2 ×3 administrations.
Animal defined daily doses, however, are currently only established at a national level.
Downregulation of protein expression was first evident at passage 18 when cells were establishing resistance at a dose of 6 nM paclitaxel and the messenger ribonucleic acid (mRNA) levels of both genes was undetectable from passage 23 onwards.
The RD was therefore established at dose level-2.
These data provide the rationale and foundation for a clinical trials program aimed at establishing a dose and route of PfSPZ that consistently achieves 100% infection rates.
The maximum tolerated dose was established at 3700 mg m−2; dose-limiting toxicities in the form of urinary incontinence, visual disturbance, and anxiety were observed at the highest dose level (4900 mg m−2).
This is why the research reviews on the subject invariably conclude that more research is necessary to establish at what dose sugar and high-fructose corn syrup start becoming what Lustig calls toxic.
Different CRC cell lines were first treated with increasing concentrations of cisplatin to establish at what doses cisplatin substantially affects cell survival.
These results revealed that all doses of PAC tested were growth inhibitory; GIMAX was established at 30 μg/mL, with higher doses exhibiting slightly less robust proliferation-inhibitory effects.
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