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Moreover, epithelial cells are firmly established as master regulators, which can dictate the threshold at which immune responses to inhaled stimuli are initiated.
Twist1 and Twist2 (Twist1–2) are two transcription factors, members of the basic helix-loop-helix family, that have been well established as master transcriptional regulators of embryogenesis and developmental programs of mesenchymal cell lineages.
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By 1960, John Sturges was established as a master of the western and he's fully in command of this transposition from medieval Japan to nineteenth-century Mexico of a tale of six honourable warriors (and a wannabe hero) hired to protect defenceless villagers from marauding bandits.
The Keck Graduate Institute of Applied Life Sciences, associated with the Claremont Colleges in California, was established as a master's-only graduate school and designed to provide California's biosciences industry with graduates who have the combination of scientific training and management skills those fields require.
SOX9 is well established as the master regulator of chondrogenesis and a factor required for the maintenance of the immature chondrocyte phenotype, and thus a potential target of RBPjk-dependent Notch function in cartilage development.
Thus far, only PGC-1α (peroxisome-proliferator-activated receptor-γ co-activator 1α), the original member of the PGC-1 family of transcriptional co-activators, has been well established as a master regulator of mitochondrial biogenesis in adipocyte and muscle cell differentiation (Puigserver et al., 1998; Wu et al., 1999; Lehman et al., 2000).
Yet he is securely established as a modern master, each new piece assuming the trappings of an event.
The Australian director Michael Rymer was chosen for the project not because he'd established himself as master of the genre, but because his earlier films ("Angel Baby," "Queen of the Damned" and especially "Perfume") demonstrated what Mr. Moore called "a dynamic use of the documentary or cinéma vérité style" that would facilitate a marriage of the fantastical and the naturalistic.
That's pretty much what the brothers are up to on the inside: having established themselves as masters of the subdued, lit-fic-style graphic novel, they're hauling the rockets back onto the launch pad and blasting off.
In 1931, with encouragement from John Gielgud, Ms. Harris and two female collaborators founded the firm Motley -- the name came from the line "Motley's the only wear" in "As You Like It" -- and gradually established themselves as masters of design for some 300 productions ranging from Shakespeare and the classics to big-budget Broadway musicals and popular Hollywood fare.
Joseph Beaumont (1616 1699), who had been established as Master of Jesus College after the Restoration but had just moved to become Master of Peterhouse, privately circulated a manuscript raising ten major objections against More's Grand Mystery of Godliness in 1663.
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