Sentence examples for established antagonists from inspiring English sources

The experiments demonstrate competitive binding between TIQ-10 and established antagonists and provide the TIQ-10 – CXCR4 binding epitope.

After all, Rumplestiltskin seems to be enough of an established antagonist for Snow White and Prince Charming that his own origin story, shown last week, potentially came years (maybe even decades?) before he was captured and locked away in the mines.

To what extent their sensory irritant action on the immersed trachea depends on TRPA1 was determined by comparing TRPA1 knockout and wild-type mice and/or using camphor 2 mM as an established antagonist.

In the R1881 competition assay, no AR antagonistic activity was detected for the ER disruptors; in contrast, the AR disruptors DDT, Vinclozolin and Nitrofen were effective in preventing hyperspeckling and transcriptional reporter gene activity at concentrations very similar (∼1.5-fold higher) to established AR antagonists (OHF, Casodex and Nilutamide).

20 Tolterodine (Tolt-IR) is an established muscarinic antagonist effective in the treatment of OAB.

Alcohol is an established folate antagonist and there is consistent evidence that a combination of alcohol consumption and low folate intakes are associated with an increased risk of colorectal cancer (Giovannucci and Willett, 1994; Giovannucci et al, 1995; La Vecchia et al, 2002).

There has been little work, however, to establish whether antagonists of endogenous anti-apoptotic proteins, such as IAPs, can improve the efficacy of targeted therapies for breast cancer.

Five different ligands representing either agonists, inverse agonists or neutral antagonists established a complex network of interactions that tuned the kinetic, energetic, and mechanical properties of functionally important structural regions of β2AR.

A clear link between JNK1 activation and proliferation in insulin-treated HASMC has not been established although JNK antagonists has been reported to inhibit proliferation of cultured SMC in other systems[ 30, 31].

Our studies (Caldwell et al, 2004, 2006) and those of others (Suzuki et al, 2004) have established that Wnt antagonists are downregulated at the earliest stages of colorectal tumorigenesis, presenting the neoplastic cells with an environment where Wnt growth factor signals are unmodulated.

In vitro studies are crucial to screen their effects [ 19], security, efficiency, and other biochemical parameters, but plant-derived bioactive molecules possess several modes of action, establishing synergic, antagonist, and polyvalent relationships with other compounds, besides suffering chemical changes due to organic metabolism, including the effects on gut microbiota [ 5, 20, 21].