Sentence examples for established and has shown from inspiring English sources

In different bacterial species, the mechanism by which CdtB blocks mammalian cell cycling has been well established, and has shown to be mediated by DNA double strand breaks induced by a direct DNase action of CDT (as reviewed [30]).

This new diagnosis is empirically established and has shown to be more valid than the ICD-10 and DSM-IV definitions, both from a clinical and a nosological viewpoint [2].

Visual rating of MTA using a 5-point scale has become fairly established and has shown fair to good inter-rater agreement [ 9, 12, 37].

The current work is in continuation of the previous established attempts and has shown significant improvement in the same direction.

Endothelial function plays a key role in determining the clinical manifestations of established atherosclerotic lesions and has shown to be suppressed by increased sympathetic tone.

Interestingly, the authors extended these findings to include a number of established colon cancer cell lines and have shown that these cancer cell lines also exhibited a large variation in demethylation.

The critical impeller speed required to eliminate gross temperature gradients within the bulk of the vessel has been established and has been shown to be influenced critically by agitator geometry and fluid properties.

Furthermore, the potential hepatotoxic effect of CDCA, as well as other bile acids, is well established and has been shown to be dose dependent [ 8].

Inflammation-mediated upregulation of TRPV1 is well established, and has been shown to involve various mechanisms including nerve growth factor (NGF) and p38MAP kinase, along with sensitisation of TRPV1 by bradykinin B2 via intracellular enzymatic pathways.

Although it is well established, and has been shown ultrastructurally very early for several toxins, that transport to the TGN and Golgi apparatus is followed by uptake into cisternae of the Golgi apparatus stacks (e.g. Sandvig et al. 1992; van Deurs et al. 1987), the involved mechanisms are still poorly understood.

We have established the method in human bone and have shown ischemia in human femoral heads removed during total hip replacement (Bøgehøj et al. 2007).