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Other less well established adverse effects include later increased risk of type II diabetes, obesity, asthma, and impaired cognitive development (DiFranza et al. 2004; Gilliland et al. 2001; Montgomery and Ekbom 2002; Von Kries et al. 2002).
Institutional care not only has established adverse effects on children's development and social relationships (Frank et al., 1996), but is also extremely expensive, costingup to 10 times what families in the same communities need to provide for a child (Desmond, Gow, Loening-Voysey, Wilson, & Stirling, 2002).
Finally, it is important to note the established adverse effects of smoking on birth outcomes.
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Whereas drug-induced lupus-like disease is an uncommon, but established, adverse effect of TNF blockade in patients with RA, SpA, or CD, these autoantibodies hitherto have not induced lupus flares.
Two classes of guidance are presented [ 3]: basic restrictions of ICNIRP are derived from the considerations related to established adverse health effects and are given in terms of dosimetric quantities, that is, induced current density for low frequency and specific absorption rate (SAR) for radio frequency and microwaves.
In addition, our results demonstrated that TNM stage also is an important prognostic factor in CRC, which is consistent with the well established adverse prognostic effect of tumor stage [ 27] and confirm that our cohort was representative and that the survival analyses were valid.
Cancer diagnosis and treatment, particularly chemotherapy, has well-established adverse effects on individuals.
A number of well-established adverse effects including nausea and severe fatigue are associated with chemotherapy [ 15].
Currently, advice in relation to diet and cancer should include the recommendation to consume adequate amounts of fruit and vegetables, but should put more emphasis on the well-established adverse effects of obesity and high alcohol intakes on cancer risk.
Glucocorticoid (GC) therapy, still widely used in the treatment of RA [ 3], is thought to be associated with an increased infection risk as well as other well-established adverse effects [ 4].
Current advice in relation to diet and cancer should include the recommendation to consume adequate amounts of fruit and vegetables, but should put most emphasis on the well-established adverse effects of obesity and high alcohol intakes.
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