To assess associations between uCTX-II or uCIIM and severity of hip pain in patients with mild-moderate hip osteoarthritis (OA) over a 2-year period, and establish whether the level of these biomarkers at baseline could estimate a specific trajectory of hip pain.
In the absence of measurement invariance, researchers are unable to establish whether the level of body dissatisfaction experienced during pregnancy is commensurate with, or perhaps greater than, that reported pre-pregnancy.
It has to be established whether the level of inhibition of FTase that was seen in PBMCs in this trial will translate into meaningful antitumour activity.
To establish whether the CLU levels found in this study were in agreement with previously reported data, we developed a method for absolute quantitative analysis.
Next, we wanted to establish whether the increased levels of GRP75/Mortalin and Calreticulin, observed to correlate with disease progression in SMA mouse models, were also measurable in skeletal muscle from human SMA patients.
To analyse the negative correlation between 8-oxoG distribution and gene density, we examined the gene expression levels to establish whether the 8-oxoG levels in genic regions associates with transcriptional activity of the genes.
Since PTEN is known to inhibit AKT activation we wished to establish whether the elevated PTEN levels evident in ODAM-expressing melanoma cells are responsible for the observed suppression of AKT activation.
DOI: http://dx.doi.org/10.7554/eLife.03638.032 Steady-state measurements of metabolite levels cannot establish whether the observed increase in CTP levels corresponds to a defect in feedback inhibition of CtpS (as predicted by our model) or by stimulating CtpS activity in some other way.
To further establish whether the increased IL-10 levels in naïve PD-1−/− mice are biologically relevant, we evaluated DC IL-12 responses to STAg injection with or without prior anti-IL-10R Ab treatment.
The positive correlation found between plasma miR-126-3p miR-126-3p miR-126-3ppted andurther test, to estApoA1h whether the drugs that affect ApoAI levels, taken by some of these prompted, also impact circulating miR-126-3p levels.
