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To establish whether the improved stability of the I539T mutant was due to rescued conformation, we in vitro translated wild-type and ΔF508 NBD1 with or without suppressor mutations and monitored changes in proteolytic digestion (Figure 4A).
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The first criterion in the case selection procedure was to establish whether the goal of improving maternal health was included in the project name or description.
In our example data set, a minimal amount of training was sufficient to attain a satisfactory interrater agreement between two independent raters, but further work is required to establish whether the agreement can be improved.
To establish whether the observed changes translates into improved performance at the whole plant level, growth rates were determined for the lines at various temperatures.
To establish whether the project met its goal of improving health for mothers and babies and its purpose of improving perinatal clinical practice, primary outcome measures were designed to evaluate change in maternal and neonatal health outcomes and 15 key evidence-based clinical practices.
There is a need for further research into strategies to overcome these barriers and establish whether the strategies proposed are beneficial towards improving the HMR process.
For example, in the context of fluid resuscitation, it is important to establish whether the resuscitation procedure under investigation effectively improves tissue perfusion and oxygenation because it is this improvement which must be considered as the ultimate purpose of resuscitation [ 8].
If the first stage is successful then the trial will continue to accrue sufficient patients to establish whether the addition of cetuximab to the standard treatment improves overall survival.
Therefore we could not evaluate clinical end points to establish whether the effects of omega-3 PUFA on adipokine profile improved clinical outcomes.
Based on the presumed importance of repetitive hyperglycaemia as the basic mechanism underlying diabetic cardiomyopathy, tests were performed to establish whether improved glycaemic control, preferably with insulin, would reverse left ventricular dysfunction.
Moreover, expression of muscle mRNA may not accurately reflect the abundance or activity of OXPHOS proteins, and further studies are warranted to establish whether improved OXPHOS gene expression in response to TZDs is associated with increased content and function of muscle mitochondria in PCOS.
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CEO of Professional Science Editing for Scientists @ prosciediting.com