Therefore, improved power to detect and validate associations in future experiments could be achieved by establishing validation populations with families, or clonal material, from the discovery population of the same species (Dillon et al. 2010).
As much as validation of analytical methods is quite well established, validation of experimental design or bioinformatics analysis is still in its infancy.
The predicted Weibull parameters are in good agreement with experimental results, which establishes validation and potential engineering value of the proposed prediction method.
Although the efficacy and safety of bortezomib is well established, validation of its benefits in patients of different ethnic backgrounds is warranted.
Hence, we tested whether the Q domains of the GAF isoforms, GAF519 and GAF582, could act as prion-like domains using established validation tools in the yeast Saccharomyces cerevisiae.
After deprotection, the functionality of "tip-PEG-acetal" was examined by a established validation method: Biotin-IgG was coupled to the tip-bound benzaldehyde functions, using NaCNBH3 for concomitant fixation of the initially formed Schiff base bonds (see Figure S5).
It is acknowledged that any new toxicogenomics-based methods will need to address established validation criteria for determination of reliability and relevance (Balls et al. 1995; ICCVAM 1997, 2003) as well as articulate the advantages and limitations of a given toxicogenomics-based test method.
Although a few studies have examined the validity of the EQ-5D in a general population of adults including older adults [ 26, 27], to date, there is no established validation work for the EQ-5D among older adults with mobility impairments.
Three criteria were set to establish clinical validation; simulator wear rates, qualitative and quantitative wear rate rankings and wear debris morphology.
To establish analytical validation best practice guidelines for NGS gene panel testing of somatic variants, a working group was convened by the Association of Molecular Pathology with liaison representation from the College of American Pathologists.
The VCS Core has attempted to establish concrete validation objectives and outcomes for NTR.
