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Using HIF-1α null mouse fibroblasts, these authors were able to establish that, of the genes that were upregulated in their study, 89% were dependent on HIF-1, as opposed to only 17% of the down-regulated genes.
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Of course, in Argand's time, the use of negative numbers was already well established; that of "even roots of negative quantities" remained controversial.
Suppose that you have established that of all rectangles with a fixed perimeter, the square has maximum area.
So we have established that of all of the channels to deliver content and services, the web is the widest and deepest.
It is well established that of EIS Nyquist plots are associated with the charge transfer resistance and the separation efficiency of the photohole-electron pairs [23].
Whereas the involvement of caspase-8 in FasL-triggered apoptosis is well established, that of caspase-10 still remains a matter of debate.
Nonetheless, it has been established that, of the CS used, only ICS and nasal CS contributed significantly to the suppression.
These data establish that activation of HIF-1α leads to deactivation of CAFs under hypoxic conditions.
Our studies clearly establish that downregulation of CAV1 increases HER2 availability at the cell surface.
These results established that overexpression of IMP1 enhanced the production of infectious MLV-luc pseudovirus.
It is well established that one of the hallmarks of senescence is DNA damage (Campisi, 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com