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While we can associate changes in atRA levels with alterations in PPARβ/δ mRNA and most likely activity, we could not establish significant changes in the mRNA levels of FABP-5, CRABP-2, RARα, or RARβ.
An explanation for the intervention's limited effectiveness may be that it was not intense enough to establish significant changes in physical activity and maintain them.
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Interestingly, we also established significant changes in the expression of proteins involved in cellular energy production and oxidative stress response.
We could not establish significant CpG methylation changes for selected regions of selected TGF-β1-responsive genes (ACTA2, COL1A1).
To the contrary, in two-parent households we found significant changes in self-report measures but little evidence was established for changes in clinician-rated data.
Fifteen EU states have intervened in the case, many seeking to make significant changes to the impact of a previous landmark judgment, known as Digital Rights Ireland, which established safeguards for retention of communications data.
Our previous analysis showed that C. acetobutylicum ccpA mutant established significant phenotypic changes (e.g., deficiency in acids re-assimilation) compared to its parental strain [ 11], suggesting that in addition to regulation of d-xylose metabolism, CcpA may be involved in regulation of other cellular processes in C. acetobutylicum.
To establish clinically significant changes in internalizing and in externalizing problems before and after the loss of a family member, the cut-off score for clinical cases, according to the Dutch standard of the YSR and ASR, in internalizing and externalizing problems was used.
Previous studies have established that significant changes in CP function accompany CNS injury, stroke and trauma [ 4, 8, 29, 30].
An alpha level less than 0.05 was established for significant changes: (1) AHD percentage change = post-AHD measure − pre-AHD measure pre-AHD measure × 100%%.
Effect Size Method was used to establish clinically significant change, therefore improvement was defined as positive change exceeding 1 Standard Deviation between baseline and follow up score in particular domain.
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