Sentence examples for establish proof of concept from inspiring English sources

Engineering demonstration reactors are nuclear reactors built to establish proof of concept for technology options that have never been built.

These findings demonstrate that etoposide can be designed as a prodrug substrate for tyrosine hydroxylase and thereby establish proof of concept for neuroblastoma directed enzyme prodrug therapy.

The Horizon Breakthrough Projects--for short-term (1 to 1.5 years) projects with a high-risk profile--are a perfect means to establish "proof of concept'" for wild and crazy ideas.

In the current work, development proceeded at first with synthetic DNA template testing to establish proof of concept for the chemistry involved, followed by the design of polymerase chain reaction (PCR -based genomic DNA assays to demonstrate PCR -basedforensic applications.

These designs are informed both by preclinical studies and by real-world research that can establish proof of concept for a novel biomarker and provide a basic understanding of the relationship between biomarker and clinical outcome.

The ESR Research Committee is working on initiatives such as the Biobanking and BioMolecular resources Research Infrastructure (BBMRI-ERIC) at the European Union (EU) level to establish proof of concept that DICOM data can be integrated into existing biobanks.

These data establish proof-of-concept that masitinib can sensitise gemcitabine-refractory pancreatic cancer cell lines and warrant further in vivo investigation.

Such evidence will help establish proof-of-concept of the possibility of interrupting STH transmission and would likely be of value to policymakers in STH-endemic countries, and partners and funders supporting STH control.

Recent experimental studies have established proof-of-concept of such fuel cells and have also shown that their performance is greatly limited by poor fuel utilization.

We also describe the role of PD analyses in clinical trials, including for MOA confirmation and dosage regimen optimization during phase 0 trials as well as for correlating molecular changes with clinical efficacy when establishing proof-of-concept in phase I/II trials.

Therefore this novel line may provide a useful additional model for establishing proof-of-concept for new therapeutic concepts.