Sentence examples for establish mutation from inspiring English sources

The aim of the present investigation was to further establish mutation frequencies for genes commonly mutated in UC, and to investigate possible positive or negative associations between mutations.

The mutants from untreated cauda spermatozoa, cauda spermatozoa originating from stem cell spermatogonia (119 days, both B[a]P- and corn oil-exposed), and the corresponding liver mutants, were characterized by DNA sequencing to establish mutation patterns.

To establish mutation drift equilibrium, a population of 100 (50 males and 50 females) were allowed to randomly mate for 1000 generations.

To establish mutation prevalence and clinical relevance of newly identified CRC-related genes, we sequenced the exomic regions of 187 recurrently mutated or pathway-related genes in tumour and blood lymphocytes in an independent cohort of 160 patients with CRC with detailed clinicopathological information by targeted capture sequencing (see online supplementary table S5 for patient information).

A historical population was simulated to establish mutation-drift equilibrium.

Reversion of the established mutation, also referred as rescue experiments, is critical for functional confirmation of targeted genes.

Once this has been established, mutation analysis for the selection of patients for whom anti-EGFR therapy will be beneficial presumably has to be extended to KRAS exon 3, PIK3CA, BRAF and NRAS.

The non-recombining nature of this chromosome region as well as the availability of a reliable molecular clock, through the established mutation rate of STRs, allows a chronological reconstruction of haplotype genealogy, when these different types of markers are analysed jointly [14] [17].

Mutations arise according to the established mutation rate and their effects are not selected a priori.

Patients were categorised into established mutation groups according to their genotype with the less severe mutation determining the group (9).

When mutations arise sequentially, each established mutation also reaches fixation; hence F ∼ 1 for small habitats, L ≪ Lc.