Relative size established importance: the ruler dwarfed the generally high official, while the tomb owner dwarfed his wife and, still more so, his children.
However, genome-wide association studies have rarely established causality between genetic variants and obesity or type 2 diabetes, despite the clearly established importance of heritability in the development of these ailments1,2,3.
Besides their established importance in the NMD process per se, NMD components have also been reported to play roles in other cellular pathways.
Replication of our association findings in the FHS cohort and the gene's established importance in both chondrogenesis/cartilage formation and obesity-related insulin resistance further suggests the gene's pleiotropic roles in both obesity and osteoporosis.
We discuss predicted functions for the gene products of MLH1, PMS2 and EPHB4, all of which have an established importance for colorectal cancer [ 67, 68].
Based on the well established importance of fungal laccases and related enzymes in lignin degradation [ 48, 49], phenoloxidases/laccases are also relevant to industrial lignocellulose pretreatment.
Although reactive oxygen species (ROS) have an established importance in the pathogenesis of cardiovascular diseases (Dhalla et al. 2000), their specific impact on autonomous nervous system activity and its reaction to inhalants remains to be established.
In this study, we included all breast cancer cases diagnosed within a population of over 3.6 million, and estimated the relative risk of death in relation to surgical workload after adjusting for a range of patient factors of established importance.
Thus, the expression pattern of cytokines and chemokines like Cxcl9, Xcl1, Cxcl10 or Ccl3 shown in Table 1 is consistent with their well established importance in the signaling mechanisms activated after allogeneic transplantation (for review see [ 21]).
