The roles of copy number variant CNVs and loss of heterozygosity in tumourigenesis are well established, for example, in the form of oncogene amplification.
It may be that the contributions of these factors are only critical at developmental stages, where heterochromatin is established (for example, in the zygote).
Similarly, the strategy of combining encapsulated anticancer drugs with a modulator has been established, for example, in the case of doxorubicin combined with valspodar.
Intervention levels have been established, for example, in Sweden: if AChE inhibition (calculated with respect to the individual preexposure level baseline) is 25%, a second measurement has to be carried out.
However, if the database provides no answer, either it fails to provide any data at all, in which case no specific information σ is available so the rule "no information without data" still applies or it can provide some data to establish, for example, that it is running in a loop.
Indeed, in a recent Forbes profile, they say they conducted extensive interviews with chefs and cookbook authors in their network in order to establish, for example, how to design a comfortable handle.
It has helped establish, for example, links among the recent sniper murders in the Washington suburbs.
For some of the TFs not previously reported to be deregulated in CRC, the involvement in the tumorigenesis of other cancers has been well established for example, SOX4 in bladder cancer and CBFB in acute myeloid leukaemia (Kundu et al, 2002; Aaboe et al, 2006).
No correlation could be established, for example, between variations in the proline pool during cold exposure and the level of freezing tolerance for Arabidopsis and Thellungiella sp. [ 32].
It is well established, for example, that an increase in speaking rate correlates with a decrease in pauses and a decrease in prosodic boundary marking (cf. [1],[1]).
