The Ca2+ response induced by the non-toxic CWE, EPM or EPS might establish a first line of defense that is then followed by a second stronger response induced by the Tox.
The Ca2+ response in the WT can be induced by the non-toxic CWE, EPM or EPS which might establish a first line of defense, followed by a stronger defense response induced by the Tox.
After the collapse of the Kamakura shogunate in 1333, Ashikaga Takauji established a second line of shogunal succession that ruled much of Japan from 1338 until 1573.
To make matters worse for the Soviets, the Afghans had established a second line of defence which consisted of seven posts, "each manned by four sentries armed with a machine gun, a mortar, and automatic rifles".
The vehicles, unmolested by the North Korean forces, departed for Pyongtaek and Cheonan, picking up stragglers along the way, eventually joining units of the 24th Infantry Division that had established a second line of defense.
The FIRM-ACT study was designed to establish a first-line chemotherapy standard which at this point is generally accepted by the ACC community as the combination of EDP-M [15].
For instance, whereas the 2004 and 2006 Canadian guidelines recommended the use of BB in all hypertensive patients aged below 60 years [ 42, 43] and the JNV 7 established BB a second line antihypertensive treatment for all patients [ 44], the 2004 and 2006 NICE guidelines downgraded the BB as an additional therapy for all patients [ 22, 24].
Univariate parametric information can be established as a first line of defense against process variation that could be detrimental to product performance.
Since the 1990s, high-dose bolus interleukin-2 (IL-2) has been established as a first-line therapy for metastatic RCC.
Although no chemotherapeutic regimen is established as a second-line therapy, recent studies reported that methotrexate, vinblastine, Adriamycin and cisplatin (MVAC) elicited a significant response in patients who failed gemcitabine and platinum (GP) chemotherapy.
