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The two subunits have essentially the same conformation and have an extensive contact area that mainly involves hydrophobic side chain interactions.
We conclude that the refolded frameshift domain adopts essentially the same conformation as the ex virio HIV-1 RNA purified under nondenaturing conditions.
The dihydroneopterin molecule is in essentially the same conformation as in the structures of canonical DHNA complexes and fits almost perfectly in the active site pocket when its pterin ring is aligned with the 8-oxoG mimic.
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In all the previously reported structures of plexinscyto, the highly conserved helical portion of the activation segment adopts essentially the same 'closed' conformation (He et al., 2009; Tong et al., 2009; Bell et al., 2011; Wang et al., 2012).
The V203A, V207A, and wild-type ADHs have essentially the same set of conformations.
Essentially the same ground-state closed conformation is observed in low-resolution structures of the CYP51 drug target complexes, while higher resolution structures demonstrate the fit induced by 4-aminopyridyl-based inhibitors bound in the active site.
While formally remaining conjecture, it is very likely that the K599-E612 interandion and the β-phosphate insertion also occur in the active conformation of human Ire1α, because the active conformations are essentially the same for all protein kinases [ 27].
Nevertheless, Lee et al. assume that the structures of TtNapA and EcNhaA show the outward-open and inward-open conformation of essentially the same antiporter.
Changing the configuration of the hydrate and reversing the propeller twist around the tertiary amine in the complex revealed a structure that was essentially the same in energy as the initial conformation (within 1 kcal mol−1).
A comparison of the J couplings for the identical methyl and aromatic residues indicates that the average χ1 conformation is essentially the same in the human and E. coli enzymes.
The MeAdoMet conformation and the active site are essentially the same as those for the complex of wt-AdoMetDC with MeAdoMet (30).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com