Changes in cell architecture, essentially linked to profound cytoskeleton rearrangements, are common features accompanying cell transformation.
His decision to resign stunned the world, because no pope had done so in nearly six centuries and because his predecessor, John Paul II, had pressed on through profound infirmity, essentially dying bit by bit on a public stage, before a worldwide audience.
A Coronation is essentially a moment of profound symbolism.
In conclusion, these results show that the pathological mechanisms occurring in the muscle of MG patients and EAMG rats are essentially similar and induce profound cellular changes, including deregulation of the IL-6 and IGF-1 pathways.
To go overnight from being a middle-class, private-school boy to, essentially, a skinhead was a profound experience.
But, if business as usual goes on until 2100, then the sea level rise challenges Miami Beach faces are truly profound," Kirtman added, essentially summarizing most of the criticism Levine received for his plan to stop flooding.
Without the shield of my notepad, I could feel and respond to what is essentially one of life's most profound moments.
For all their eccentric habits and physical peculiarities, Irving's characters are essentially realistic, capable of making a profound emotional connection with the reader.
But when you display one image at a time in a series that's essentially customized, based on time, something profound happens.
Sirota argues that, through his donation, Arnold has co-opted an institution with a well-known reputation for middle-of-the-road judiciousness effectively to join a campaign with profound political implications -- and essentially on one side of the debate.
Talent is a gift, and though it must be nurtured, we are essentially born with certain abilities--profound dexterity, perfect pitch, innate sense of composition--or we aren't.
