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This result clearly suggests that the influence of the TRα gene on thermogenesis is essentially mediated through p43 expression and is induced by mitochondrial activity.
This result, associated with a previous study indicating that TRα gene invalidation in mice induced a significant decrease in body temperature [21], clearly suggests that the influence of the TRα gene on thermogenesis is essentially mediated through p43 expression and is induced at the level of mitochondrial activity.
Thus the repair mechanisms were essentially mediated through active gene action.
Our results thus provide evidence that restoration of death receptor-induced cell death by hyperthermia is essentially mediated through c-FLIP aggregation.
To date, it was believed that such a role was essentially mediated through the ability of PKC to down-regulate the DNMT expression at the mRNA level [ 56].
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A natural idea would be that a normative determination principle involves a mapping essentially mediated by norms, or normative facts.
Thus, the effect of integration policy outputs on corresponding policy outcomes is essentially mediated by their effect on individual capabilities and aspirations (see Fig. 1).
Together our data indicate that CHIKV entry in its target cells is essentially mediated by clathrin-independent, Eps15-dependent endocytosis.
Finally, these results also provide evidence that the thermogenic T3 influence is probably essentially mediated by the mitochondrial T3 receptor.
Our main interest was the identification of hyaluronan-based ECM molecules, which essentially mediate the neuroprotective properties of PNs.
Biological systems essentially comprise protein "machines" [ 23] and biological function is mediated through associations between proteins, either directly through physical contact, or indirectly within protein complexes, or as part of the same biological pathway.
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