HTT exon1-Q23 is especially susceptible, showing only about 10% aggregation in the presence of a 1.5-fold molar excess of HTTNT at 1000 h, a time when the peptide without inhibitor has essentially aggregated to completion.
Interestingly, it differentially affected the distribution pattern of mitochondria, with latrunculin B-treated PC12-ND6 cells displaying mitochondria essentially aggregated around the MTOC (microtubule-organizing centre) (see Supplementary Figure S3B) and nocodazole-treated PC12-ND6 cells harbouring mitochondria evenly localized to the perinuclear region (see Supplementary Figure S3C).
"We've hired a bunch of very young people in New York and Hong Kong and they're essentially aggregating as a breaking news service: when anything appears from a reliable news organisation, quickly write two or three paragraphs and get it out there," he said.
The app works by essentially aggregating clothing from multiple different sources, doing away with the need to browse and shop various different e-commerce and deals sites to find clothes on sale and in your personal style.
He noted that beyond the big online ad platforms, there's an expansive landscape of large and small publishers — in fact, many of the big ad players (including AOL, which owns TechCrunch) are essentially aggregating those publishers for advertisers.
ThirdLove, however, uses big data analytics to essentially aggregate the long tail, turning a single person's quest into one from many people, and aggregating images of all the busts to help build the design of the bras, which it executes by tapping into more precise manufacturing techniques.
At some point there will also be an optional program to submit a child's information (anonymously, of course) to help create a database of what accommodations in which places and cases led to what outcomes — essentially aggregating information direct from the source.
Founded by the team behind Gumtree, Zoopla and Qype, Adzuna essentially aggregates job listings across the web to offer a single destination to search for a job.
Cooked up by Amsterdam-based Tone.fm (also see the now deadpooled Twones), it's a service that essentially aggregates (mostly indie) music from around the Web based on genres.
The company claims it didn't want people to mix up the daily deals it offers with its Bing Deals service, which essentially aggregates daily deals from a range of third-party providers.
This developer has had 20 apps released into the Windows Marketplace yesterday, and all of them essentially aggregate content from different sections of CNN and the BBC's websites.
