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Their essentiality lies in the fact that they cannot be synthesized de novo within the human or animal organism [ 300].
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The advantage of using such hub proteins as drug targets lies in their essentiality, non-replaceable position in the PIN and lower rate of mutation, which can help to counter bacterial resistance.
Interest in metals like zinc (Zn) and copper (Cu), which are required for metabolic activity in organisms, lies in the narrow "window" between their essentiality and toxicity.
Figure 6: In silico elucidation of the mechanisms of essentiality for the five genes selectively essential in ccRCC.
Essentiality tests suggested that neither sig1 nor sig2 is essential under all conditions.
So the epistemic essentiality claim seems right.
There is a notion of museum essentiality that is by no means beyond debate".
Figure 4: Validation of predicted gene essentiality in ccRCC.
CHD1 shows synthetic essentiality in PTEN-deficient breast cancer.
— lies.
PDFs essentiality was first demonstrated in Escherichia coli in 1994.
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