Therefore, whereas panthothenate is commonly thought to be essential, this essentiality is strain specific and absent in C. difficile strain 630.
Despite the precedence for successful drugs that act through agonist relationships with non-essential molecules, essentiality is a desirable character of genes to be pursued by a target-centric approach.
These initial genome-scale mutant libraries provided an accurate early genome-wide snapshot of the S. cerevisiae genome, such as the observation that ∼20% of the genes are essential, and that essentiality is dependent on the experimental conditions.
Selecting features associated with gene essentiality is fundamental to predict essential genes in feature-based models.
Selecting features associated with gene essentiality is necessary to identify essential genes through machine learning approaches.
A second problem with metrics based upon lists of essential genes is that gene essentiality is dependent upon strain, media, and environmental conditions (for example, [ 39] identify mutants which are inositol auxotrophs only at elevated temperatures).
In the budding yeast Saccharomyces cerevisiae, the subunits of any given protein complex are either mostly essential or mostly nonessential, suggesting that essentiality is a property of molecular machines rather than individual components.
Twelve drug targets showed up to be non-essential in both networks (Table 1), although their essentiality is experimentally validated for the parasite.
Gene essentiality is context dependent; hence a gene may be essential only under a given set of growth conditions, but not under other conditions.
Hart and his fellows have pointed out that the essentiality is a special property of protein complex and essential proteins are often highly clustered in certain protein complexes [ 13].
Zotenko et. al. found that essentiality is due to the involvement of hubs in essential complex biological modules, groups of densely connected proteins with shared biological function that are enriched in essential proteins [ 12].
