Sentence examples for essentiality from from inspiring English sources

This study establishes benchmarks for gene essentiality prediction, presents a community resource for future comparison with this benchmark, and provides insights into factors influencing the ability to predict gene essentiality from functional genetic screens.

Integrating them together will enable us to address essentiality from all these perspectives simultaneously.

However, a rational method for applying knowledge of essentiality from orthologues in other species is lacking.

We compared our characterizations of system-level properties with characterizations of essentiality from the basis of multiple (previous) validated studies.

Information on gene essentiality from a transposon site hybridisation (TraSH) mutagenesis study for Mtb [ 23] has also been incorporated in the decision criteria.

To begin, a large dataset of E. coli gene essentiality from the Keio Collection [ 23], combined from four published datasets [ 10, 23- 25], was assembled.

With the advances in high throughput technologies, a large number of protein protein interactions are available, which makes it possible to detect proteins' essentialities from the network level.

With the advances in high throughput technologies, a large number of protein-protein interactions are available, which have produced unprecedented opportunities for detecting proteins' essentialities from the network level.

C. elegans genes that lacked mammalian orthologues were much less likely to be essential; the probability of essentiality decreased from 16%to8%8% for a gene selected at random, and was only 6% if the gene had paralogues (Table 1, Figure 3).

Our approach is novel because we infer SL interactions directly from tumour data and validate these using essentiality data from tumour cell lines, and is different from earlier approaches [ 24– 28].

Current essential gene databases provide only binary essentiality data from genome-wide experiments.