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This suggests that besides considering LREs as indicators of learners' engagement with the language which satisfies the criteria (task utility, task naturalness and essentiality) for a task to be considered as an effective task, task engagement should also be considered as an equally important criterion.
The tight link between dysregulated A-to-I editing and diseases highlights the essentiality for a balanced regulation and regulators responsible for maintaining the balance are promising therapeutic targets.
For C. elegans, the probability of essentiality for a gene without paralogues selected at random was 18%; this probability increased to 38% if the gene had an orthologue in D. melanogaster and to 51% if an orthologue existed in the more distant relative, S. cerevisiae.
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In addition to this essentiality for host cells, an increase in copper uptake has also been reported as a defense mechanism against intracellular pathogens because of its toxic properties.
Overall, the estimated essentiality score for a gene in the adult definitive erythroid lineage was not a good predictor of its score in the primitive erythroid lineage.
Several computational studies are also available [ 33, 34], adding to the resource base, making it feasible to address complex issues such as gene essentiality for this pathogen from an integrated perspective.
Although the numerical weighting cannot give an exact probability of essentiality for each uncharacterized gene, the weightings should give an estimation of the relative likelihood of being essential for any two genes being considered as candidate targets.
We reasoned that, if there was a correlation between gene regulation and essentiality for infection, down-regulated genes would not display a virulence defect.
Inferring essentiality information for an organism from another organism may be facilitated by investigating a closely related organism as we did with S. typhimurium being rather closely related to E. coli.
Findings from this study support the possible use of enteric viral pathogens for environmental monitoring and argue the importance and essentiality for such monitoring activity to ensure a safe use of recreational waters.
Here we address the rarely considered significance of 8-oxoG, such as its optimal levels in DNA and RNA under a given condition, essentiality for normal cellular physiology, evolutionary role, and ability to soften the effects of oxidative stress in DNA, and the harmful consequences of its repair, as well as its importance in transcriptional initiation and chromatin relaxation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com