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This is essential validation for investigators using the Qiagen NRSP8 array for porcine functional genomics and for using the pig in modeling important physiological problems.
The robustness of our experimental standards is supported by several essential validation steps: first, mean strain values measured in ctr condition correlated well with independent datasets of the Mouse Phenome Database.
FASSS meets essential validation criteria for quantification of a common structural abnormality in clinical trials of axial spondyloarthritis.
The FASSS therefore meets essential validation criteria for further assessment in patients with axial SpA in studies of treatment effect and as a surrogate marker for structural damage progression.
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Such a database is essential for validation of both existing and novel image processing procedures and can only be created by a consortium.
However, typical in silico models are not suitable for regulatory purposes, as they have not taken into account one or more factors essential for validation, quality assurance, or for a specific application of a given compound.
This study represents an essential methodological validation of a more chemically defined type of synthetic urine that can be applied to study mechanisms of bacteriuria and we conclude will offer a useful in vitro model to investigate the basis of some of the most common infections of humans.
Six phases are recommended for developing effective biomarkers, with longitudinal studies considered essential for validation [ 31].
To facilitate the comparison of microarray expression data between laboratories it is essential that validation methodologies be critically examined.
While the specificity of shRNA is essential for validation of a target, small-molecule enzyme inhibitors are more likely than shRNA to translate towards clinical application.
There are 55 non-gene associated reactions included in the model that lack experimental evidence but are essential for validation and prediction of a physiological phenotype in silico (Additional File S1C).
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