Sentence examples for essential upstream from inspiring English sources

The receptor-interacting serine/threonine protein kinase 1 (Ris1) is an essential upstream signaling molecule in tumor-necrosis-factor-α-induced necroptosis.

In response to DNA damaging agents such as ionizing radiation, PARP-1 has been shown to be an essential upstream mediator of NF-κB activation [44], [45].

Cbl inactivation might thus restore thymic differentiation in SLP-76-/-Y3F mice by allowing Vav1 activation and permitting T cell development in absence of normally essential upstream events.

These findings demonstrate that CD40 is an essential upstream mediator of ERK and NFκB activation in DC treated with B7-DC XAb and link CD40 to the enhanced survival phenotype observed in DCXAb.

Further, to study the essential upstream events in the IKKβ-IκBα mediated NF-κB pathway involving intermediate adaptor proteins such as TRADD, RIP and TRAF-2, we next examined their expression levels and interaction using co-immunoprecipitation studies.

Cheng et al. reported that LKB1 was an essential upstream regulator of p53-mediated anoikis [ 27].

IKKβ is an essential kinase upstream of IκBα, crucial for the activation of NF-κB through the canonical pathway.

Together, these results indicate that Vret plays an essential role upstream of Piwi, and possibly Aub, in the primary piRNA pathway.

However, our results provide strong evidence that RIPK1 does not have an obligatory role in necroptosis signaling, challenging models which suggested that RIPK1 has an essential role upstream of RIPK3 and is required for its activation.

These factors could directly modulate 5S RNP integration, potentially by bridging interactions between the 5S RNP and the preribosome, or alternatively be essential for upstream steps in the process.

Fourth, non-essential genes immediately upstream of and co-transcribed with essentials may be incorrectly scored as essential due to polarity of the transposon insertion.