It has been postulated that effective degradation of DNA from dying cells is essential to prevent priming of the immune system against chromatin self-antigens, and impaired chromatin degradation has been proposed as a mechanism for the development of antinuclear autoimmunity [9], [10].
The discovery of TACI expression on DC is key, because DC are widely acknowledged to be essential to the priming of naïve T cells for a productive immune response in vivo [ 44].
Breast-feeding is essential to promote or prime neonatal neurodevelopment, and China is among the countries that use TCV; therefore, controlling for these variables is important in neurodevelopmental studies (Dórea 2007a).
Therefore, our results show that PKCδ-nuclear translocation is an essential key step to prime the sequence of molecular events which culminate in the late caspase 3 activation and in the irreversible commitment of cells to apoptosis.
Ensuring naïve T cells are primed for activity specifically against their tumour cell target is essential to prevent autoimmunity, while priming a pool of T cells recognising a variety of tumour antigens is important for achieving maximal tumour killing and preventing escape variants.
Britain believes Mr. Trimble to be essential to progress in Ulster, and Prime Minister Tony Blair left no doubt today which candidate he favored.
A strong, Labour voice is essential, to take on the new prime minister as well as build broad support across the country.
From the perspective of the proposed model, this nicking flexibility might be essential to generate two nicks in order to prime first and second strand cDNA synthesis.
The first example is different from the last two in that it seems that we can know a priori that being such that there are infinitely many primes is essential to Socrates whereas it seems that we can know only a posteriori that being human and originating from s and e are also essential to him.
