Sentence examples for essential to mount from inspiring English sources

Gene deletion studies indicate that the p53 polyproline domain is essential to mount an effective apoptotic response to stress and inhibit tumorigenesis.

30 Collaboration among specialist centres, such as the Genetic Frontotemporal Dementia Initiative, 31 with access to well characterised cohorts of patients with FTD will be essential to mount large scale trials of rationally targeted therapies that may finally allow us to treat these devastating diseases.

Nuclear translocation of NF-κB induces transcription of proinflammatory cytokine genes essential to mounting a protective immune response and host defense.

Nuclear translocation of NF-kB induces transcription of pro-inflammatory cytokine genes essential to mounting a protective immune response and host defence [ 5].

Binding and presentation of peptide antigens by the MHC molecules of antigen presenting cells (APCs) is essential to mounting an effective immune response.

"Craig Mackail-Smith missed the end of last season through injury but goals from him and Leonardo Ulloa are essential for Albion to mount another push for the top-flight".

A prerequisite is that the essential signals required to mount an HPC response are known, and that these signals are specific to HPCs and do not, for example, activate HSCs and cause excessive fibrosis.

Therefore these proteins are essential for pancreatic β-cells to mount an initial rapid insulin secretory response, which is followed by a slower KATP-independent release of insulin.

Scientists are also experimenting with altering essential proteins in hosts that bacteria use to mount infections.

DNA-induced TNFα secretion proved to be essential in vivo, as mice deficient in the TNF receptor were unable to mount an acute inflammatory response to dsDNA.

As empirical evidence continues to mount demonstrating mito-nuclear discordance [ 21, 22], the use of nuclear markers has become essential to species delimitation and the study of speciation.