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While simple gene deletion methods can be used in the case of non-essential byproduct pathways, more sophisticated approaches are required when competitive fluxes are essential to host cellular functions.
It was therefore impossible to remove pAMI5, which strongly suggests that this replicon might be essential to host viability.
These mutualistic symbionts are generally vertically transmitted from parent to offspring and can be either essential to host survival (obligate, primary) or facultative (secondary) [ 8, 9].
Similar(57)
It is becoming increasingly apparent that Staphylococcus aureus are able to survive engulfment by macrophages, and that the intracellular environment of these host cells, which is essential to innate host defenses against invading microorganisms, may in fact provide a refuge for staphylococcal survival and dissemination.
Usually, either non-essential food constituents are transformed into compounds essential to the host, or compounds that cannot or are poorly metabolized by the host itself are utilized by the bacteria.
One major obstacle in targeting host factors is that many which are utilized by HIV-1 are also essential to the host.
However, there is not yet a proven case of any of these Helitron- or Pack-MULE-generated "new" genes having actually acquired a genetic function essential to its host.
Since interferon signaling is essential to baseline host antiviral resistance in the lungs [17], [18], we investigated whether treatment with NTHi lysate was capable of inducing an interferon response.
Healthy gut is essential to promote host health and prevent organ dysfunction in sepsis.
Despite massive gene loss, more genes were retained for biosynthesis of amino acids predicted to be essential to the host.
Prior to HSCT, an intense conditioning regimen is essential to reduce host tumor burden and/or auto-reactive lymphocytes.
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