While the later stages of the PhAT deal with the clinical validation of the therapeutic hypothesis, early preclinical experiments are essential to define a number of the PhAT parameters, including identification of biomarkers and early demonstration of efficacy and proof of mechanism.
There has been no consensus on what parameters are essential to define a mechanical breath as being APRV, and thus, APRV settings have been inconsistent over the three decades since it was first described.
It is essential to define a good practice guidelines for creating a successful S&T network and/or aligning existing networks, based on the understanding of how other networks have succeeded or failed at forming, governing, and funding their activities and to what extent these networks have met their goals.
Therefore, we propose that DIMM cells display, on average, a more highly-active secretory profile that conventional interneurons or motorneurons and that DIMM is therefore essential to define a prevalent class of Neurosecretory Neuron in the fly (Figure 11, top left).
So it would be essential to define a specific normal range and cut-off value for premenopausal and postmenopausal women respectively.
Remarkably, little information has been produced on miRNA precursors in rice although this is essential to define a miRNA gene and confirm its expression.
In this context, a better understanding of potential future carbon stock changes in the Harvest Wood Products pool is essential to define an effective mitigation strategy, capable to maximize the sum of the contribution of different mitigation options.
Although the use of PCR has been essential to defining the problem, a more rapid diagnosis would be an important tool for prompt medical treatment.
McBain understood that a specially tuned ear was essential to defining the people of the city that he called Isola.
