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When is it essential to be essential?
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The partial shutdown shone a bright light on what were deemed to be essential versus non-essential government agencies and positions.
When American Airlines' Sabre and United Airlines Apollo Computerized Reservations Systems were found to be essential facilities and thus essential to all airlines attempting to sell tickets through travel agencies, American and United were forced to make these services available to other airlines under more equitable terms.
Only proteins annotated as essential in both datasets were considered to be essential here.
As discussed above, reactions predicted to be essential are not necessarily essential during all time points.
The orthologous gene of an essential gene is highly likely to be essential as well [ 18].
Out of all the 5093 proteins in the yeast network, 1167 proteins are essential, 3591 are non-essential, and the rest 335 are still unknown to be essential or non-essential.
However, in A. nidulans the presence of extracellular glucose proved not to be essential, while glucose phosphorylation was essential, for CreA repression.
The roles of Ni in animal metabolism and physiology are largely uncharacterized; although, it appears to be essential, yet specific essential roles continue to evade elucidation [ 5].
Acencio et al. [ 25] find that proteins located in nuclear subcellular compartments tend to be essential, because most essential biological processes for cell viability take place in nuclear.
Classification of E. coli genes into three groups – (E) genes essential for cell growth (essential), (N) those dispensable for cell growth (non-essential), and (U) those unknown to be essential or non-essential – was based on the comprehensive experimental analysis of [ 47].
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