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A web interface to the database and loop modeling application is freely available at http://rloom.mpimp-golm.mpg.de Contact: [email protected]; [email protected]; [email protected] Loop structures (i.e. regions without secondary structure) are not only essential structural elements accounting for the flexibility and structural diversity of RNA molecules.
It is a kind of distillation of the landscape into its essential structural elements.
"From the thirteenth to the twentieth centuries, the essential structural elements of the university have remained largely the same," he wrote.
Although arches, vaults and domes were essential structural elements in ancient engineering works, their structural analysis presents a challenge to modern designers.
The SARs studies highlighted the importance of the piperazine substituted 5,8-dihydropteridine-6,7-dione 5,8-dihydropteridine-6,7-dione 5,8-dihydropteridine-6,7-dione 5,8-dihydropteridine-6,7-dione
In addition to the wild-type, this study also looks at specific XPA67-80 mutants in complex with the ERCC1 central domain and thus contributes to defining the conformational determinants for binding, as well as all of the essential structural elements necessary for the rational design of an XPA-based, ERCC1-specific inhibitor.
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However, 4-isopropylphenol was still approximately 7-fold less active than BPA, indicating that the phenol backbone structure is an essential structural element for the binding to ERR-γ.
The essential structural element for the glucosyltransferase activity in the clostridial enzymes is a motif containing the amino acid sequence DXD, which is involved in Mn2+-dependent binding of UDP-glucose in the catalytic cleft [3].
The structure highlights helix α2 in the central region of the CTD as an essential structural element in the recognition of the B subunit.
Thus, it appears that by alkylating catalytic residues and taking the place of a disulfide and/or an essential selenenylsulfide structural element (see Figure 8 for the model of NAPQI binding to TrxR1), NAPQI inactivates TrxR.
Therefore, it is essential that the structural elements and the connections between them have the ability to resist a degree of damage in order to prevent progressive collapse.
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