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These results suggest that the Ce HCF-1 protein plays conserved regulatory but not essential roles in certain chromatin modifications and in successful development.
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Research over the past 20 years has demonstrated that reactive oxygen species (ROS) have an essential role in certain cellular events.
Perhaps more importantly, when it's not clear how we, as a society, will address a problem, government plays an essential role in normalizing certain kinds of solutions.
TLRs have been considered to play essential roles in the pathogenesis of RA, and certain TLRs, such as TLR2, 3, 4 and 7, exhibit a high expression in RA synovium [ 40, 41].
Some symbionts can play essential roles in the insect gut, compensating for diets deficient in certain nutrients or containing recalcitrant organic compounds.
A number of strategies aimed at interfering with TGF-β1-induced cellular responses have been developed, although there remains concern that TGF-β1 plays essential roles in regulating inflammation and acts as a tumour suppressor in certain contexts.
Studies have shown that certain amino acids play essential roles in CA biosynthesis.
6– 10 In addition to signaling molecules, certain transcription factors also play essential roles in the formation and maintenance of lymphatic vessels.
These two transcription factors in the nucleus trigger an anti-aging transcriptional program that is aimed at sustaining high levels of certain proteins known for their essential roles in extending organismal longevity [ 46].
The rationale of this strategy is that replacement amino acids that are tolerated at certain given positions do not play essential roles in protein structure, stability or activity.
However, it has become clear that certain genes derived from retrotransposons play essential roles in mammalian development as newly acquired endogenous genes.
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