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The self-reactive CD4 T-cells play an essential role in triggering and sustaining organ-specific autoimmune diseases.
In line with these findings, loss- and gain-of-function experiments reveal that WNT11 plays an essential role in triggering cell migration and invasion (Fig. 4, Supplementary Figures 4 and 6).
Significant up-regulation of TRAF5 gene expression may play an essential role in triggering potentiation by EtOH of HIV-1 gp120-induced neuronal apoptosis at early stages of interaction.
In neurons, the resting concentration of calcium in dendritic spines, where it plays an essential role in triggering synaptic plasticity, corresponds to only a few ions in this small volume [ 7], indicating that calcium dynamics can be highly stochastic [ 8].
Mutations or chemicals that impair or block the transfer of electrons along the ETC to form ROS efficiently suppress the phenotypes of mod1 mutant plants, indicating that the ROS generated in mitochondria through ETC plays an essential role in triggering plant PCD.
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Solar filament eruptions play a crucial role in triggering coronal mass ejections (CMEs).
MBD4 might also have an essential role in the triggering of apoptosis upon DNA damage (Zabkiewicz and Clarke, 2004).
In this study, we present evidence that Trim17 plays an essential role in the triggering of neuronal apoptosis via its E3 activity.
Mitochondria play an essential role in apoptosis triggered by various chemical agents (Sareen et al. 2006).
LBP plays an essential role in recognizing LPS and triggering the downstream inflammatory cascade.
The nature of the DC subtypes and the particular PRR triggered plays an essential role in modulating the strength, quality, and memory of adaptive immune responses (Pulendran and Ahmed 2006; Steinman 2008).
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