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The balance between proteases and antiproteases plays an essential role in the pathogenesis of emphysema.
Various studies indicate that NO plays also an essential role in the pathogenesis of migraine [22, 23].
Impaired GABAergic inhibitory synaptic transmission plays an essential role in the pathogenesis of selective neuronal cell death following transient global ischemia.
Accumulating evidence suggests that inflammation plays an essential role in the pathogenesis of atherosclerosis and that circulating inflammatory markers predict future cardiovascular events.
Here, we show that metabolites of neurons play essential role in the pathogenesis of Alzheimer's disease (AD).
Angiotensin II, one of the major active components in the rennin-angiotensin system, plays an essential role in the pathogenesis of atherosclerosis [3].
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There is growing evidence that MDCB play essential roles in the pathogenesis of gliomas.
Current evidence suggest that PACAP plays essential roles in the pathogenesis of migraine via modulating the function of nociceptive neurons within the trigeminocervical system.
Leukocyte adhesion to the vascular endothelium and subsequent transendothelial migration play essential roles in the pathogenesis of cardiovascular diseases such as atherosclerosis.
These factors play essential roles in the pathogenesis of RA.
Taken together, these observations strongly suggest that NIA plays essential roles in the pathogenesis of DRPLA.
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