Sentence examples for essential role in normal from inspiring English sources

Given its essential role in normal cell proliferation, the depletion of polyamines and the inhibition of polyamine synthesis lead to growth cessation and consequently cell death3,11,12.

Epidermal growth factor receptor (EGFR) plays an essential role in normal development, tumorigenesis and malignant biology of human cancers, and is known to undergo intracellular trafficking to subcellular organelles.

These studies demonstrated cofilin-1 plays an essential role in normal functions of podocytes.

An increasing number of studies indicate that adult neurogenesis plays an essential role in normal memory function [11], [33].

Because EGFP was shown to impair actin-myosin interactions in muscle cells [3] and to induce dilated cardiomyopathy in EGFP mice [4], it is tempting to speculate that actin ubiquitination might play an essential role in normal muscle functioning and that its deregulation by EGFP causes the above mentioned phenotypes.

IL-6-STAT3 signalsog also plays an essential role in normal liver regeneration after hepatic injury.

Extracellular matrix interactions have essential roles in normal physiology and many pathological processes.

This is because the products of its catalysis – polyamines – play essential roles in normal cell growth and differentiation1.

These lipid mediators play essential roles in normal cellular homeostasis as well as in a number of disease states.

KAT6A has essential roles in normal haematopoietic stem cells4,5,6 and is the target of recurrent chromosomal translocations, causing acute myeloid leukaemia7,8.

These results imply that Hh signaling may not play essential roles in normal development of the embryonic ventral body wall, but may be implicated in omphalocele pathogenesis.